Article

Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adults

2020-07-31

Abstract excerpt

<h4>ABSTRACT</h4> Exposure to early-life stress (ELS) increases risk for poor mental and physical health outcomes that emerge at different stages across the lifespan. Yet, how age interacts with ELS to impact the expression of specific phenotypes remains largely unknown. An established limited-bedding paradigm was used to induce ELS in mouse pups over the early postnatal period. Initial analyses focused on the hi...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9351a2ae-717b-5e62-aa13-2bcffc475e55
DOI: 10.1101/2020.07.30.229690

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adultsDOI 10.1101/2020.07.30.229690Read

Proteomic and mitochondrial adaptations to early-life stress are distinct in juveniles and adultsSemantic proximity Read

Effects of early-life stress on peripheral and central mitochondria in male mice across agesSemantic proximity Read

Early-life stress exposure impacts the hippocampal synaptic proteome in a mouse model of Alzheimer’s disease: age- and pathology-dependent effects on mitochondrial proteinsSemantic proximity Read

The Mitochondrion as Potential Interface in Early-Life Stress Brain ProgrammingSemantic proximity Read

Mice Undergo Organ-Specific Transcriptional and Metabolic Remodeling During Late AdolescenceSemantic proximity Read

Multi-Omics Data Integration Reveals Sex-Dependent Hippocampal Programming by Maternal High-Fat Diet during Lactation in Adult Mouse OffspringSemantic proximity Read

Molecular mechanisms of early life stress—Lessons from mouse modelsSemantic proximity Read

Developmental programming of mitochondrial biology: a conceptual framework and reviewSemantic proximity Read

Transcriptomic analysis reveals mitochondrial pathways associated with distinct adolescent behavioral phenotypes and stress response.Semantic proximity Read

Molecular roadmap of the healthy stress response in the mouse hippocampusSemantic proximity Read

Age- and sex-associated alterations in hypothalamic mitochondrial bioenergetics and inflammatory-associated signaling in the 3xTg mouse model of Alzheimer’s diseaseSemantic proximity Read

Maternal stressors disrupt mouse placental proteome and fetal brain development in a sex-specific fashion through inflammation and oxidative stressSemantic proximity Read