Article
Proteomic analysis of brain proteins in APP/PS-1 human double mutant knock-in mice with increasing amyloid β-peptide deposition: insights into the effects of in vivo treatment with N-acetylcysteine as a potential therapeutic intervention in mild cognitive impairment and Alzheimer's disease.
Proteomics - 1 Nov 2011
Robinson Renã A S, Joshi Gururaj, Huang Quanzhen, Sultana Rukhsana, Baker Austin S, Cai Jian, Pierce William, St Clair Daret K, Markesbery William R, Butterfield D Allan
Abstract excerpt
Proteomics analyses were performed on the brains of wild-type (WT) controls and an Alzheimer's disease (AD) mouse model, APP/PS-1 human double mutant knock-in mice. Mice were given either drinking water or water supplemented with N-acetylcysteine (NAC) (2 mg/kg body weight) for a period of five months. The time periods of treatment correspond to ages prior to Aβ deposition (i.e. 4-9 months), resembling human mild...
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