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Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathology

2021-03-22

Abstract excerpt

<h4>ABSTRACT</h4> The sustained proliferation of microglia is a key hallmark of Alzheimer’s disease (AD), accelerating its progression. Here, we sought to understand the long-term impact of the early and prolonged microglial proliferation observed in AD, hypothesising that extensive and repeated cycling would engender a distinct transcriptional and phenotypic trajectory. We found that the early and sustained micr...

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Literature Corpus work
40b20946-b1dc-5e8f-9dad-937cdfc9082d
DOI
10.1101/2021.03.22.436174
Open publication

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Replicative senescence dictates the emergence of disease-associated microglia and contributes to Aβ pathologyDOI 10.1101/2021.03.22.436174
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