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Aging, Cellular Senescence, and Alzheimer’s Disease

11 Feb 2022

Abstract excerpt

Aging is the greatest risk factor for late-onset Alzheimer's disease (LOAD), which accounts for >95% of Alzheimer's disease (AD) cases. The mechanism underlying the aging-related susceptibility to LOAD is unknown. Cellular senescence, a state of permanent cell growth arrest, is believed to contribute importantly to aging and aging-related diseases, including AD. Senescent astrocytes, microglia, endothelial cells,...

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PMID: 35216123
DOI: 10.3390/ijms23041989

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