Article

RNA structure profiling at single-cell resolution reveals new determinants of cell identity

2023-03-14

Abstract excerpt

<title>Abstract</title> <p>RNA structure is critical for multiple steps in gene regulation. However, how structures of transcripts differ both within and between individual cells is unknown. Here, we develop a method enabling the simultaneous determination of transcript structure and abundance at single-cell resolution and apply it to human embryonic stem cells (hESCs) and differentiating neurons. Remarkably, RNA...

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Literature Corpus work: 44eb93ac-04f3-59bc-ac7d-bdaa5946e8d8
DOI: 10.21203/rs.3.rs-2564210/v1

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