Pre-division TCF1 drop determines long-term CD8 T cell fates

Abstract excerpt

<h4>SUMMARY</h4> T Cell Factor 1 (TCF1) is a master transcription factor controlling T cell development and peripheral T cell differentiation during infection, cancer, and autoimmunity. TCF1 is highly expressed in naive CD8 T cells but must be downregulated as T cells proliferate to become effectors. If and how TCF1 plays a role during T cell priming prior to cell cycle entry is unknown. Surprisingly, we found th...

Topics

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• Acetylation
• Cancer Immunotherapy and Biomarkers
• CAR-T cell therapy research
• CD4-Positive T-Lymphocytes
• CD8-Positive T-Lymphocytes
• Cell Lineage
• Immune Cell Function and Interaction
• T-cell and B-cell Immunology

Identifiers and source

Literature Corpus work

facc988b-592a-5517-9237-fa3fd50ff122

DOI

10.1101/2025.10.06.680655