Article

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell states

2025-10-10

Abstract excerpt

<h4>ABSTRACT</h4> Heterogeneous T cell states are critical in immune responses and have been explored by CRISPR-based and synthetic domain-swapped transcription factor (TF) screens, yielding novel insights and immunotherapeutics. However, a scalable strategy to map TFs in primary human T cells is lacking, which limits our understanding of the functions of critical TFs. We therefore adapted a transposon-based TF m...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: fa5c2220-2e85-53f3-8475-30b60a92e033
DOI: 10.1101/2025.10.09.681414

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Scalable transcription factor mapping uncovers the regulatory dynamics of natural and synthetic transcription factors in human T cell statesDOI 10.1101/2025.10.09.681414Read

A unified atlas of CD8 T cell dysfunctional states in cancer and infectionSemantic proximity Read

A Toolbox for Binary and Rheostat-like Modulation of TOX Expression via Genome and Epigenome Editing in Primary Human T cellsSemantic proximity Read

Reproducible single cell annotation of programs underlying T-cell subsets, activation states, and functionsSemantic proximity Read

Genular: An Integrated Platform for Defining Cellular Identity and Function through Single-Cell Gene Expression and Multi-Domain Biological DataSemantic proximity Read

Orthogonal CRISPR screens to identify transcriptional and epigenetic regulators of human CD8 T cell functionSemantic proximity Read

Mapping the functional impact of non-coding regulatory elements in primary T cells through single-cell CRISPR screensSemantic proximity Read

Genome-scale mapping of variant, enhancer and gene function in primary human CD4+ T cellsSemantic proximity Read

Unraveling transposable element-mediated regulatory landscape in diverse human immune cellsSemantic proximity Read

Functional Inference of Gene Regulation using Single-Cell Multi-OmicsSemantic proximity Read

Reproducible single-cell annotation of programs underlying T cell subsets, activation states and functionsSemantic proximity Read

Improving prediction of core transcription factors for cell reprogramming and transdifferentiationSemantic proximity Read

Calling Cards: a customizable platform to longitudinally record protein-DNA interactions over time in cells and tissuesSemantic proximity Read