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Transcriptional and epigenetic regulators of human CD8+ T cell function identified through orthogonal CRISPR screens

9 Nov 2023

Abstract excerpt

Abstract Clinical response to adoptive T cell therapies is associated with the transcriptional and epigenetic state of the cell product. Thus, discovery of regulators of T cell gene networks and their corresponding phenotypes has potential to improve T cell therapies. Here we developed pooled, epigenetic CRISPR screening approaches to systematically profile the effects of activating or repressing 120...

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PMID: 37945901
DOI: 10.1038/s41588-023-01554-0

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