Article

Retrovirus-induced leukemia – hijack of T-cell activation mechanisms revealed by single-cell analysis

2021-09-01

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-1) mainly infects CD4 + T-cells and induces chronic, persistent infection in infected individuals with some progressing to develop adult T-cell leukemia/lymphoma (ATL). Whilst HTLV-1 alters cellular differentiation, activation and survival, it is unknown whether and how these changes contribute to malignant transformation of infected T-cells. In this study, we used single-...

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Literature Corpus work: 54e25961-cf67-5df2-863c-23e377c8740a
DOI: 10.1101/2021.09.01.458291

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