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Transcriptional rewiring in CD8+ T cells: implications for CAR-T cell therapy against solid tumours

27 Sept 2024

Abstract excerpt

T cells engineered to express chimeric-antigen receptors (CAR-T cells) can effectively control relapsed and refractory haematological malignancies in the clinic. However, the successes of CAR-T cell therapy have not been recapitulated in solid tumours due to a range of barriers such as immunosuppression, poor infiltration, and tumour heterogeneity. Numerous strategies are being developed to overcome these...

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PMID: 39399500
DOI: 10.3389/fimmu.2024.1412731

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