Article

Common origin for effector and regulatory follicular and tissue-Adapted CD4+ T cells in Non-Small Cell Lung Cancer

2025-09-18

Abstract excerpt

<h4>ABSTRACT</h4> Tumor-invaded lymph nodes (LNs) serve as critical hubs for anti-tumor immunity, yet their role in orchestrating immune responses remains poorly understood. Using integrated single-cell RNA sequencing, T cell receptor sequencing, and chromatin accessibility profiling, we analyzed CD4+ T cells from matched blood, tumor-invaded LNs, and tumors of treatment-naïve non-small cell lung cancer patients....

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Literature Corpus work: 034f00a2-5765-5dd1-9cea-8fa04b213863
DOI: 10.1101/2025.09.17.674622

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