Article

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation

2021-07-26

Abstract excerpt

CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations in the laboratory. This class of gene drives relies on CRISPR-Cas9 cleavage of a target sequence and copying (‘homing’) therein of the gene drive element from the homologous chromosome. However, target site mutations that are resistant to cleavage yet maint...

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Literature Corpus work: 4054edee-8697-5c49-b01e-0a9b3a12bcda
DOI: 10.1101/2021.07.26.453797

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