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Article

Resistance to a CRISPR-based gene drive at an evolutionarily conserved site is revealed by mimicking genotype fixation.

PLoS genetics - 1 Oct 2021

Fuchs Silke, Garrood William T, Beber Anna, Hammond Andrew, Galizi Roberto, Gribble Matthew, Morselli Giulia, Hui Tin-Yu J, Willis Katie, Kranjc Nace, Burt Austin, Crisanti Andrea, Nolan Tony

Abstract excerpt

CRISPR-based homing gene drives can be designed to disrupt essential genes whilst biasing their own inheritance, leading to suppression of mosquito populations in the laboratory. This class of gene drives relies on CRISPR-Cas9 cleavage of a target sequence and copying ('homing') therein of the gene drive element from the homologous chromosome. However, target site mutations that are resistant to cleavage yet...

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Identifiers

PMID: 34610011
DOI: 10.1371/journal.pgen.1009740
PMCID: PMC8519452

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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