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Article

Engineering resilient gene drives for sustainable malaria control by predicting, testing and overcoming target site resistance in Anopheles gambiae.

PLoS biology - 1 Jul 2026

Morianou Ioanna, Phillimore Lee, Khatri Bhavin S, Marston Louise, Gribble Matthew, Burt Austin, Bernardini Federica, Hammond Andrew M, Nolan Tony, Crisanti Andrea

Abstract excerpt

CRISPR-based gene drives are selfish genetic elements with the potential to spread through entire insect populations for sustainable vector control. Gene drives designed to disrupt the reproductive capacity of females can suppress laboratory populations of the malaria mosquito, Anopheles gambiae. However, any suppressive intervention will inevitably exert an evolutionary pressure for resistance, and the...

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Identifiers

PMID: 42406843
DOI: 10.1371/journal.pbio.3003879
PMCID: PMC13395382

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