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Measuring the impact of genetic heterogeneity and chromosomal inversions on the efficacy of CRISPR-Cas9 gene drives in different strains of <i>Anopheles gambiae</i>

2023-04-01

Abstract excerpt

The human malaria vector Anopheles gambiae is becoming increasingly resistant to insecticides, spurring the development of genetic control strategies. CRISPR-Cas9 gene drives can modify a population by creating double-stranded breaks at highly specific targets, triggering copying of the gene drive into the cut site (‘homing’), ensuring its inheritance. The DNA repair mechanism responsible requires homology betwee...

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Literature Corpus work
ed13dd4c-d9d3-5d91-9d8a-138a54e9a854
DOI
10.1101/2023.03.31.535088
Open publication

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Measuring the impact of genetic heterogeneity and chromosomal inversions on the efficacy of CRISPR-Cas9 gene drives in different strains of <i>Anopheles gambiae</i>DOI 10.1101/2023.03.31.535088
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