Article

Engineering gene drive docking sites in a haplolethal locus in <i>Anopheles gambiae</i>

2025-03-03

Abstract excerpt

<h4>ABSTRACT</h4> Gene drives are selfish genetic elements which promise to be powerful tools in the fight against vector-borne diseases such as malaria. We previously proposed population replacement gene drives designed to better withstand the evolution of resistance by homing through haplolethal loci. Because most mutations in the wild-type allele that would otherwise confer resistance are lethal, only successf...

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Literature Corpus work: ad44251f-85e2-50b3-9741-d24efb12655b
DOI: 10.1101/2025.03.03.641265

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