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Article

Mutant allele formation and inheritance during Cas9/guide RNA-mediated gene drive in a population modification mosquito strain for human malaria control.

Genetics - 12 Nov 2025

Carballar-Lejarazú Rebeca, Pham Thai Binh, Tushar Taylor, James Anthony A

Abstract excerpt

Gene-drive systems are under development for the population modification of anopheline vectors of human malaria parasites. The key to their success is the fixation of genes in target mosquito populations that encode molecules preventing parasite transmission. High-efficiency Cas9/guide RNA (gRNA)-based gene-drive systems can facilitate this objective. A potential challenge to these systems is the presence of...

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PMID: 40845150
DOI: 10.1093/genetics/iyaf176
PMCID: PMC12606424

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