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Article

Abundance of conserved CRISPR-Cas9 target sites within the highly polymorphic genomes of Anopheles and Aedes mosquitoes.

Nature communications - 18 Mar 2020

Schmidt Hanno, Collier Travis C, Hanemaaijer Mark J, Houston Parker D, Lee Yoosook, Lanzaro Gregory C

Abstract excerpt

A number of recent papers report that standing genetic variation in natural populations includes ubiquitous polymorphisms within target sites for Cas9-based gene drive (CGD) and that these "drive resistant alleles" (DRA) preclude the successful application of CGD for managing these populations. Here we report the results of a survey of 1280 genomes of the mosquitoes Anopheles gambiae, An. coluzzii, and Aedes...

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Identifiers

PMID: 32188851
DOI: 10.1038/s41467-020-15204-0
PMCID: PMC7080748

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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