CD33 and SHP-1/PTPN6 Interaction in Alzheimer’s Disease

Abstract excerpt

Large-scale genetic studies have identified numerous genetic risk factors that suggest a central role for innate immune cells in susceptibility to Alzheimer’s disease (AD). CD33, an immunomodulatory transmembrane sialic-acid binding protein expressed on myeloid cells, was identified as one such genetic risk factor associated with Alzheimer’s disease. Several studies explored the molecular outcomes of genetic varia...

Topics

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• Alternative Splicing
• Alzheimer Disease
• Exons
• Genetic Predisposition to Disease
• Microglia
• Polymorphism, Single Nucleotide
• Protein Tyrosine Phosphatase, Non-Receptor Type 6
• Sialic Acid Binding Ig-like Lectin 3

Identifiers and source

Literature Corpus work

404967cf-d1fa-57d5-b0b4-2445b2c907da

DOI

10.20944/preprints202407.0168.v1