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Article

CD33 and SHP-1/PTPN6 Interaction in Alzheimer's Disease.

Genes - 13 Sept 2024

Beckers Lien, Rashid Mamunur, Lee Annie J, Chatila Zena K, Tamucci Kirstin A, Talcoff Ryan C, Hall Jennifer L, Bennett David A, Vardarajan Badri N, Bradshaw Elizabeth M

Abstract excerpt

Large-scale genetic studies have identified numerous genetic risk factors that suggest a central role for innate immune cells in susceptibility to Alzheimer's disease (AD). CD33, an immunomodulatory transmembrane sialic acid binding protein expressed on myeloid cells, was identified as one such genetic risk factor associated with Alzheimer's disease. Several studies explored the molecular outcomes of genetic...

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Share to Alzheimer Disease
Share to PTPN11 gene

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

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Share to Polymorphism, Single Nucleotide

Share to Protein Tyrosine Phosphatase, Non-Receptor Type 6

Share to Sialic Acid Binding Ig-like Lectin 3

Source

Open in PubMed Open full text

Identifiers

PMID: 39336795
DOI: 10.3390/genes15091204
PMCID: PMC11431297

Genes

CD33
PTPN6
PTPN11

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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