CD33-CD45 Interaction Reveals a Mechanistic Link to Alzheimer’s Disease Susceptibility

Abstract excerpt

The innate immune gene CD 33, encoding a myeloid inhibitory sialic acid-binding receptor, is associated with Alzheimer’s disease (AD) susceptibility. The AD-associated rs3865444 CC risk variant reduces splicing of the sialic acid-binding domain and increases expression of the full-length (sialic acid-binding) CD33 isoform seven-fold compared to the rs3865444 AA protective genotype. Here we identify CD45 as an...

Topics

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• Alternative Splicing
• Alzheimer Disease
• Exons
• Genetic Predisposition to Disease
• Microglia
• Polymorphism, Single Nucleotide
• Protein Tyrosine Phosphatase, Non-Receptor Type 6
• Sialic Acid Binding Ig-like Lectin 3

Identifiers and source

Literature Corpus work

c87b5954-e199-56d9-a5af-63117b2fc0dc

DOI

10.1101/2025.07.28.667311