Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex.

doi:10.1016/j.neurobiolaging.2014.09.023

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Article

Association of CD33 polymorphism rs3865444 with Alzheimer's disease pathology and CD33 expression in human cerebral cortex.

Neurobiology of aging - 1 Feb 2015

Walker Douglas G, Whetzel Alexis M, Serrano Geidy, Sue Lucia I, Beach Thomas G, Lue Lih-Fen

Abstract excerpt

Recent findings identified the minor A allele present in the single-nucleotide polymorphism rs3865444 in the CD33 gene as being associated with the reduced risk of developing Alzheimer's disease (AD). CD33 (Siglec-3) is an immune function protein with anti-inflammatory signaling, cell adhesion, and endocytosis functions with sialic acid-modified proteins or lipids as ligands. Its involvement in AD pathologic...

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PMID: 25448602
DOI: 10.1016/j.neurobiolaging.2014.09.023
PMCID: PMC4315751

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