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Article

Deletion of Alzheimer's disease-associated CD33 results in an inflammatory human microglia phenotype.

Glia - 1 Jun 2021

Wißfeld Jannis, Nozaki Ichiro, Mathews Mona, Raschka Tamara, Ebeling Christian, Hornung Veit, Brüstle Oliver, Neumann Harald

Abstract excerpt

Genome-wide association studies demonstrated that polymorphisms in the CD33/sialic acid-binding immunoglobulin-like lectin 3 gene are associated with late-onset Alzheimer's disease (AD). CD33 is expressed on myeloid immune cells and mediates inhibitory signaling through protein tyrosine phosphatases, but the exact function of CD33 in microglia is still unknown. Here, we analyzed CD33 knockout human THP1...

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PMID: 33539598
DOI: 10.1002/glia.23968

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