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Article

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

Neuron - 22 May 2013

Griciuc Ana, Serrano-Pozo Alberto, Parrado Antonio R, Lesinski Andrea N, Asselin Caroline N, Mullin Kristina, Hooli Basavaraj, Choi Se Hoon, Hyman Bradley T, Tanzi Rudolph E

Abstract excerpt

The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that regulates innate immunity but has no known functions in the brain. We have previously shown that the CD33 gene is a risk factor for Alzheimer's disease (AD). Here, we observed increased expression of CD33 in m...

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Identifiers

PMID: 23623698
DOI: 10.1016/j.neuron.2013.04.014
PMCID: PMC3706457

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23623698-2026-09-04.1. Manifest publication-graph-cohort-2026-09-04.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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