Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

doi:10.1016/j.neuron.2013.04.014

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Article

Alzheimer's disease risk gene CD33 inhibits microglial uptake of amyloid beta.

Neuron - 22 May 2013

Griciuc Ana, Serrano-Pozo Alberto, Parrado Antonio R, Lesinski Andrea N, Asselin Caroline N, Mullin Kristina, Hooli Basavaraj, Choi Se Hoon, Hyman Bradley T, Tanzi Rudolph E

Abstract excerpt

The transmembrane protein CD33 is a sialic acid-binding immunoglobulin-like lectin that regulates innate immunity but has no known functions in the brain. We have previously shown that the CD33 gene is a risk factor for Alzheimer's disease (AD). Here, we observed increased expression of CD33 in microglial cells in AD brain. The minor allele of the CD33 SNP rs3865444, which confers protection against AD, was...

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PMID: 23623698
DOI: 10.1016/j.neuron.2013.04.014
PMCID: PMC3706457

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