CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.

doi:10.1523/JNEUROSCI.1224-13.2013

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Article

CD33 Alzheimer's risk-altering polymorphism, CD33 expression, and exon 2 splicing.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 14 Aug 2013

Malik Manasi, Simpson James F, Parikh Ishita, Wilfred Bernard R, Fardo David W, Nelson Peter T, Estus Steven

Abstract excerpt

Genome-wide association studies are identifying novel Alzheimer's disease (AD) risk factors. Elucidating the mechanism underlying these polymorphisms is critical to the validation process and, by identifying rate-limiting steps in AD risk, may yield novel therapeutic targets. Here, we elucidate the mechanism of action of the AD-associated polymorphism rs3865444 in the promoter of CD33, a member of the sialic...

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Identifiers

PMID: 23946390
DOI: 10.1523/JNEUROSCI.1224-13.2013
PMCID: PMC3742922

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