CD33 and clusterin interact biophysically and genetically to modulate Alzheimer risk

Abstract excerpt

<h4>ABSTRACT</h4> We report the results of structural, functional and genetic studies on the CD33 sialic acid- binding receptor that reveal how non-coding variants in CD33 alter risk for Alzheimer’s disease (AD). The full-length CD33 M isoform, whose expression is upregulated by non-coding AD-risk alleles, preferentially forms dimers at the cell surface, where they interact with AD-related proteins (clusterin an...

Topics

Open a Topic to create a Post that cites this publication.

• Alzheimer Disease
• Alzheimer's disease research and treatments
• Genetic Predisposition to Disease
• Microglia
• Neuroinflammation and Neurodegeneration Mechanisms
• Polymorphism, Single Nucleotide
• Protein Tyrosine Phosphatase, Non-Receptor Type 6
• Sialic Acid Binding Ig-like Lectin 3

Identifiers and source

Literature Corpus work

0482028d-e933-51c3-bf9a-12ad7a275fc2

DOI

10.1101/2025.07.29.667318