Article
CD33 rs2455069 SNP: Correlation with Alzheimer's Disease and Hypothesis of Functional Role.
International journal of molecular sciences - 26 Mar 2022
Tortora Fabiana, Rendina Antonella, Angiolillo Antonella, Di Costanzo Alfonso, Aniello Francesco, Donizetti Aldo, Febbraio Ferdinando, Vitale Emilia
Abstract excerpt
The CD33 gene encodes for a member of the sialic-acid-binding immunoglobulin-type lectin (Siglec) family, and is one of the top-ranked Alzheimer’s disease (AD) risk genes identified by genome-wide association studies (GWAS). Many CD33 polymorphisms are associated with an increased risk of AD, but the function and potential mechanism of many CD33 single-nucleotide polymorphisms (SNPs) in promoting AD have yet to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.