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Article

The yeast polo kinase Cdc5 regulates the shape of the mitotic nucleus.

Current biology : CB - 1 Dec 2014

Walters Alison D, May Christopher K, Dauster Emma S, Cinquin Bertrand P, Smith Elizabeth A, Robellet Xavier, D'Amours Damien, Larabell Carolyn A, Cohen-Fix Orna

Abstract excerpt

Abnormal nuclear size and shape are hallmarks of aging and cancer. However, the mechanisms regulating nuclear morphology and nuclear envelope (NE) expansion are poorly understood. In metazoans, the NE disassembles prior to chromosome segregation and reassembles at the end of mitosis. In budding yeast, the NE remains intact. The nucleus elongates as chromosomes segregate and then divides at the end of mitosis to...

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Identifiers

PMID: 25454593
DOI: 10.1016/j.cub.2014.10.029
PMCID: PMC4255140

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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