Article

Ectopic activation of the polar body extrusion pathway triggers cell fragmentation in preimplantation embryos

2022-12-23

Abstract excerpt

Cell fragmentation occurs during physiological processes, such as apoptosis, migration, or germ cell development. Fragmentation is also commonly observed during preimplantation development of human embryos and is associated with poor implantation prognosis during Assisted Reproductive Technology (ART) procedures. Despite its biological and clinical relevance, the mechanisms leading to cell fragmentation are unclea...

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Literature Corpus work: 3a906335-b7fb-5d84-914c-a52bde0d7536
DOI: 10.1101/2022.12.22.521568

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