Article

A universal scaling law for mitotic spindles across eukaryotes driven by chromosome crowding

2025-03-06

Abstract excerpt

Cells regulate the size of their internal structures to maintain function in diverse biological settings 1 . The mitotic spindle, a molecular micro-machine responsible for chromosome segregation 2 , must scale to accommodate genomes varying in size by over 10,000-fold across eukaryotes 3 . Yet, how spindle biomechanics adapts to vastly different genome sizes remains unknown. Here, we uncover a universal spindle...

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Literature Corpus work: 74634bd5-800c-5091-a9d3-6f20085a1a06
DOI: 10.1101/2025.03.05.641650

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