Article
Mouse Rif1 is a key regulator of the replication-timing programme in mammalian cells.
The EMBO journal - 12 Sept 2012
Cornacchia Daniela, Dileep Vishnu, Quivy Jean-Pierre, Foti Rossana, Tili Federico, Santarella-Mellwig Rachel, Antony Claude, Almouzni Geneviève, Gilbert David M, Buonomo Sara B C
Abstract excerpt
The eukaryotic genome is replicated according to a specific spatio-temporal programme. However, little is known about both its molecular control and biological significance. Here, we identify mouse Rif1 as a key player in the regulation of DNA replication timing. We show that Rif1 deficiency in primary cells results in an unprecedented global alteration of the temporal order of replication. This effect takes...
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