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Article

The temporal program of chromosome replication: genomewide replication in clb5{Delta} Saccharomyces cerevisiae.

Genetics - 1 Dec 2008

McCune Heather J, Danielson Laura S, Alvino Gina M, Collingwood David, Delrow Jeffrey J, Fangman Walton L, Brewer Bonita J, Raghuraman M K

Abstract excerpt

Temporal regulation of origin activation is widely thought to explain the pattern of early- and late-replicating domains in the Saccharomyces cerevisiae genome. Recently, single-molecule analysis of replication suggested that stochastic processes acting on origins with different probabilities of activation could generate the observed kinetics of replication without requiring an underlying temporal order. To...

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Identifiers

PMID: 18832352
DOI: 10.1534/genetics.108.094359
PMCID: PMC2600925

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