Article

Novel Single-Cell Multiomics Approach to Analyze Replication Timing and Gene Expression in Mouse Preimplantation Embryos

2025-01-03

Abstract excerpt

Analysis of a cell’s replication timing (RT) provides insight into how genes replicate, early or late, during the S-phase of the cell cycle. RT is cell-type specific, inheritable, and has been correlated to gene expression in normal and diseased states. However, most studies have been limited to somatic cells. Very little is known about RT control in early mouse embryos, and how it correlates with the start of tra...

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Literature Corpus work: cf70c634-cf50-560d-a139-a2e3ebf2b402
DOI: 10.1101/2025.01.02.631157

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