Article

Phospholipid isotope tracing reveals β-catenin-driven suppression of phosphatidylcholine metabolism in hepatocellular carcinoma

2023-10-16

Abstract excerpt

<h4>Background and Aims</h4> Activating mutations in the CTNNB1 gene encoding β-catenin are among the most frequently observed oncogenic alterations in hepatocellular carcinoma (HCC). HCC with CTNNB1 mutations show profound alterations in lipid metabolism including increases in fatty acid oxidation and transformation of the phospholipidome, but it is unclear how these changes arise and whether they contribute t...

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Literature Corpus work: 3fdcd6a1-a237-534a-bd75-2946d9e1dfb8
DOI: 10.1101/2023.10.12.562134

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