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Fatty acid oxidation drives Acetyl-CoA-dependent H3K9ac reprogramming to promote adaptive resistance to BRAFV600E inhibition in thyroid cancer

2025-07-14

Abstract excerpt

<title>Abstract</title> <p> BRAF-targeted therapy is a promising strategy for thyroid cancer. However, its efficacy is limited by drug resistance. This study elucidates the role of fatty acid oxidation (FAO) in mediating adaptive resistance to BRAF <sup>V600E</sup> inhibition (BRAFi) in thyroid cancer. Through integrated transcriptomic and metabolomic analyses, we demonstrate that BRAFi by vemurafenib (PLX4032...

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Literature Corpus work
97d53206-db46-5b0a-a753-4b62f88c4db3
DOI
10.21203/rs.3.rs-6898631/v1
Open publication

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