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Article

β-catenin-activated hepatocellular carcinomas are addicted to fatty acids.

Gut - 1 Feb 2019

Senni Nadia, Savall Mathilde, Cabrerizo Granados David, Alves-Guerra Marie-Clotilde, Sartor Chiara, Lagoutte Isabelle, Gougelet Angélique, Terris Benoit, Gilgenkrantz Hélène, Perret Christine, Colnot Sabine, Bossard Pascale

Abstract excerpt

OBJECTIVES: CTNNB1-mutated hepatocellular carcinomas (HCCs) constitute a major part of human HCC and are largely inaccessible to target therapy. Yet, little is known about the metabolic reprogramming induced by β-catenin oncogenic activation in the liver. We aimed to decipher such reprogramming and assess whether it may represent a new avenue for targeted therapy of CTNNB1-mutated HCC. DESIGN: We used mice with...

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Share to beta Catenin
Share to Carcinoma, Hepatocellular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epoxy Compounds

Share to Fatty Acids

Share to Gene Expression Regulation, Neoplastic

Share to Liver Neoplasms

Share to Oxidation-Reduction

Share to PPAR alpha

Source

Identifiers

PMID: 29650531
DOI: 10.1136/gutjnl-2017-315448

Genes

CTNNB1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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