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Article

Fine-Tuning Lipid Metabolism by Targeting Mitochondria-Associated Acetyl-CoA-Carboxylase 2 in BRAFV600E Papillary Thyroid Carcinoma.

Thyroid : official journal of the American Thyroid Association - 1 Sept 2021

Valvo Veronica, Iesato Asumi, Kavanagh Taylor R, Priolo Carmen, Zsengeller Zsuzsanna, Pontecorvi Alfredo, Stillman Isaac E, Burke Suzanne D, Liu Xiaowen, Nucera Carmelo

Abstract excerpt

Background: BRAFV600E acts as an ATP-dependent cytosolic kinase. BRAFV600E inhibitors are widely available, but resistance to them is widely reported in the clinic. Lipid metabolism (fatty acids) is fundamental for energy and to control cell stress. Whether and how BRAFV600E impacts lipid metabolism regulation in papillary thyroid carcinoma (PTC) is still unknown. Acetyl-CoA carboxylase (ACC) is a rate-limiting...

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Identifiers

PMID: 33107403
DOI: 10.1089/thy.2020.0311
PMCID: PMC8558082

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