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CHPT1–LCAT rewires lipolysis towards ferroptosis

2026-03-16

Abstract excerpt

Ferroptosis is driven by iron-dependent lipid peroxidation, yet how metabolic flux through central lipid pathways is selectively routed towards pro-ferroptotic lipid species remains unclear. Here, through an unbiased chemical–genetic screen targeting core metabolic enzymes, we identify diacylglycerol (DAG) as a licensing lipid intermediate whose pro-ferroptotic activity depends on its intracellular routing. System...

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Identifiers and source

Literature Corpus work
49501733-9f2d-549b-85b6-ed7aeb58d617
DOI
10.64898/2026.03.15.711301
Open publication

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CHPT1–LCAT rewires lipolysis towards ferroptosisDOI 10.64898/2026.03.15.711301
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