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YAP disrupts bile acid homeostasis to drive cancer-associated cachexia

2026-02-03

Abstract excerpt

Cancer-associated cachexia is a severe metabolic syndrome marked by dramatic loss of adipose and muscle mass. Although preclinical models have advanced our understanding of cachexia, there are still no approved therapies due to the limited insights into the mechanisms underlying tissue wasting. Here, we utilise a YAP-driven model of liver cancer in zebrafish, which rapidly develops cachexia, to uncover an evolutio...

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Identifiers and source

Literature Corpus work
9ab30023-b7c6-5c7d-a249-97fc572b9640
DOI
10.64898/2026.02.01.702698
Open publication

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YAP disrupts bile acid homeostasis to drive cancer-associated cachexiaDOI 10.64898/2026.02.01.702698
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