Cholangiocarcinoma cells direct fatty acids to support membrane synthesis and modulate macrophage phenotype.

doi:10.1097/HC9.0000000000000717

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Cholangiocarcinoma cells direct fatty acids to support membrane synthesis and modulate macrophage phenotype.

Hepatology communications - 1 Jun 2025

Dei Cas Michele, Mantovani Stefania, Oliviero Barbara, Zulueta Aida, Montavoci Linda, Falleni Monica, Tosi Delfina, Morano Camillo, Penati Sara, Chiocchetti Annalisa, Sinella Riccardo, Barbero Mazzucca Camilla, Donadon Matteo, Soldani Cristiana, Piccolo Gaetano, Barabino Matteo, Bianchi Paolo Pietro, Maestri Marcello, Lleo Ana, Banales Jesus M, Mondelli Mario U, Caretti Anna

Abstract excerpt

BACKGROUND AND AIMS: Cholangiocarcinoma (CCA) is a globally rare, increasingly incident cancer. Metabolic reprogramming is common in cancer cells, and altered lipid homeostasis favors tumor development and progression. Previous studies have described lipid deregulation in HCC cells, while in CCA, the lipidome profile is still poorly characterized. METHODS: We used liquid chromatography-tandem mass spectrometry to...

Read the complete abstract on PubMed

Topics

Humans
Cholangiocarcinoma
Bile Duct Neoplasms
Fatty Acids

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Macrophages

Male

Phenotype

Female

Middle Aged

Cell Membrane

Lipid Metabolism

Tandem Mass Spectrometry

Lipid Droplets

Aged

Source

Open in PubMed Open full text

Identifiers

PMID: 40408281
DOI: 10.1097/HC9.0000000000000717
PMCID: PMC12106197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 23 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cholangiocarcinoma cells direct fatty acids to support membrane synthesis and modulate macrophage phenotype.PMID 40408281Read ↗

Aberrant lipid metabolism in hepatocellular carcinoma cells as well as immune microenvironment: A reviewSemantic proximity Read ↗

Lipid alterations in chronic liver disease and liver cancerSemantic proximity Read ↗

Macrophage metabolism, phenotype, function, and therapy in hepatocellular carcinoma (HCC).Semantic proximity Read ↗

Metabolic reprogramming and its clinical implication for liver cancerSemantic proximity Read ↗

Intrahepatic Macrophage Reprogramming Associated with Lipid Metabolism in Hepatitis B Virus-Related Acute-on-Chronic Liver FailureSemantic proximity Read ↗

Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinomaSemantic proximity Read ↗

Role of Long Chain Acyl-CoA Synthetases in MASH-driven Hepatocellular Carcinoma and FerroptosisSemantic proximity Read ↗

Hepatocellular Carcinoma Overcomes Lipid Depletion by Utilizing Serine for Phospholipid Synthesis and Enhanced SurvivalSemantic proximity Read ↗

Simultaneous Activation of Beta‐Oxidation and De Novo Lipogenesis in MASLD ‐ HCC : A New ParadigmSemantic proximity Read ↗

Exploring the significance of fatty acid metabolism reprogramming in the pathogenesis of cancer and anticancer therapySemantic proximity Read ↗

ACSL3 is an unfavorable prognostic marker in cholangiocarcinoma patients and confers ferroptosis resistance in cholangiocarcinoma cellsSemantic proximity Read ↗

The altered lipidome of hepatocellular carcinomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.