microRNA-21 promotes dysregulated lipid metabolism and hepatocellular carcinoma

Abstract excerpt

<h4>Backgrounds and Aims</h4> The prevalence of hepatocellular carcinoma (HCC) is rising in parallel with increasing obesity and metabolic dysfunction-associated steatohepatitis (MASH). MicroRNAs are key post-transcriptional regulators of gene expression and are attractive targets for HCC therapy. Here we sought to identify and characterize dysregulated microRNAs in MASH-driven HCC (MASH-HCC). <h4>Approach and Re...

Topics

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• Animals, Genetically Modified
• Cancer-related molecular mechanisms research
• Carcinoma, Hepatocellular
• Chemical and Drug Induced Liver Injury
• Gene Knockout Techniques
• Heterografts
• Liver Disease Diagnosis and Treatment
• MicroRNA in disease regulation

Identifiers and source

Literature Corpus work

96658b1b-3717-5912-a96a-dfb143c5e484

DOI

10.1101/2025.07.19.665686