Hepatocellular Carcinoma Overcomes Lipid Depletion by Utilizing Serine for Phospholipid Synthesis and Enhanced Survival

Abstract excerpt

<title>Abstract</title> <p>Metabolic vulnerabilities of hepatocellular carcinoma (HCC) remain largely unexplored, though deregulation in these processes is a hallmark of cancer. HCC cells exhibit a marked dependence on lipids and have distinct responses to lipid depletion. Challenging HCC cells phenotype by lipid depletion, we studied their reaction through functional assays, lipidomic, metabolic, transcriptomic...

Topics

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• Cancer, Hypoxia, and Metabolism
• Cancer, Lipids, and Metabolism
• Cholesterol
• Gene Expression Regulation, Neoplastic
• Lipid metabolism and biosynthesis
• Liver Disease Diagnosis and Treatment
• Mutation
• Neoplasms

Identifiers and source

Literature Corpus work

43cbb57e-8d25-5947-831f-765b934dea88

DOI

10.21203/rs.3.rs-3823677/v1