Article

Transferability of polygenic risk scores depending on demography and dominance coefficients

2024-08-08

Abstract excerpt

The genetic liability to a complex phenotype is calculated as the sum of genotypes, weighted by effect size estimates derived from summary statistics of genome-wide association study (GWAS) data. Due to different allele frequencies (AF) and linkage disequilibrium (LD) patterns across populations, polygenic risk scores (PRS) that were developed on one population drop drastically in predictive performance when trans...

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Literature Corpus work: 3fcf301d-2ac2-56a9-a758-b2c8a022a307
DOI: 10.1101/2024.08.07.24311645

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