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Article

Investigations on transferability of polygenic risk scores depending on demography and dominance coefficients.

HGG advances - 9 Jul 2026

Fohler Leonie, Latifi Edita, Mayr Andreas, Maj Carlo, Staerk Christian, Klinkhammer Hannah, Krawitz Peter M

Abstract excerpt

The genetic liability to a complex phenotype can be assessed using polygenic risk scores (PRSs) and is calculated as the sum of genotypes weighted by effect-size estimates derived from summary statistics of genome-wide association study (GWAS) data. Due to different allele frequencies (AFs) and linkage disequilibrium (LD) patterns across populations, PRSs developed in one population drop drastically in predictive...

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Identifiers

PMID: 41902401
DOI: 10.1016/j.xhgg.2026.100595
PMCID: PMC13125173

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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