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Article

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.

American journal of human genetics - 6 Apr 2017

Martin Alicia R, Gignoux Christopher R, Walters Raymond K, Wojcik Genevieve L, Neale Benjamin M, Gravel Simon, Daly Mark J, Bustamante Carlos D, Kenny Eimear E

Abstract excerpt

The vast majority of genome-wide association studies (GWASs) are performed in Europeans, and their transferability to other populations is dependent on many factors (e.g., linkage disequilibrium, allele frequencies, genetic architecture). As medical genomics studies become increasingly large and diverse, gaining insights into population history and consequently the transferability of disease risk measurement is...

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Identifiers

PMID: 28366442
DOI: 10.1016/j.ajhg.2017.03.004
PMCID: PMC5384097

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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