Article

Human demographic history impacts genetic risk prediction across diverse populations

2016-08-23

Abstract excerpt

The vast majority of genome-wide association studies are performed in Europeans, and their transferability to other populations is dependent on many factors (e.g. linkage disequilibrium, allele frequencies, genetic architecture). As medical genomics studies become increasingly large and diverse, gaining insights into population history and consequently the transferability of disease risk measurement is critical. H...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: b9faa955-6947-5a41-99e1-03f4e01b43e3
DOI: 10.1101/070797

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Human demographic history impacts genetic risk prediction across diverse populationsDOI 10.1101/070797Read

Human Demographic History Impacts Genetic Risk Prediction across Diverse Populations.Semantic proximity Read

Determining the driving factors shaping genetic architecture of complex traits in recently admixed populationsSemantic proximity Read

Investigations on transferability of polygenic risk scores depending on demography and dominance coefficients.Semantic proximity Read

Inclusion of Variants Discovered from Diverse Populations Improves Polygenic Risk Score TransferabilitySemantic proximity Read

Transferability of polygenic risk scores depending on demography and dominance coefficientsSemantic proximity Read

Capturing additional genetic risk from family history for improved polygenic risk predictionSemantic proximity Read

Importance of human demographic history knowledge in genetic studies involving multi-ethnic cohortsSemantic proximity Read

Theoretical and empirical quantification of the accuracy of polygenic scores in ancestry divergent populationsSemantic proximity Read

Capturing additional genetic risk from family history for improved polygenic risk prediction.Semantic proximity Read

How robust are cross-population signatures of polygenic adaptation in humans?Semantic proximity Read

Demographic history impacts stratification in polygenic scoresSemantic proximity Read

Negative selection on complex traits limits phenotype prediction accuracy between populations.Semantic proximity Read