Article

Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression between patients

2024-12-12

Abstract excerpt

Genetic alterations alone cannot account for the diverse phenotypes of cancer cells. Even cancers with the same driver mutation show significant transcriptional heterogeneity and varied responses to therapy. However, the mechanisms underpinning this heterogeneity remain under-explored. Here, we find that novel enhancer usage is a common feature in acute lymphoblastic leukemia (ALL). In particular, KMT2A::AFF1 ALL...

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Literature Corpus work: 3fc6e5fe-4d85-558c-83f6-d728d49aaa4f
DOI: 10.1101/2024.12.08.627394

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