Article

Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architectures

2023-02-15

Abstract excerpt

<h4>SUMMARY</h4> B-cell lineage acute lymphoblastic leukemia (B-ALL) is comprised of diverse molecular subtypes and while transcriptional and DNA methylation profiling of B-ALL subtypes has been extensively examined, the accompanying chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq for 10 B-ALL molecular subtypes in primary ALL cells from...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 267e8fbf-19ae-5b13-a87b-b01d48151d2a
DOI: 10.1101/2023.02.14.528493

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Epigenomic mapping in B-cell acute lymphoblastic leukemia identifies transcriptional regulators and noncoding variants promoting distinct chromatin architecturesDOI 10.1101/2023.02.14.528493Read

Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulatorsSemantic proximity Read

Heterogeneity in chromatin structure drives core regulatory pathways in B-cell Acute Lymphoblastic LeukemiaSemantic proximity Read

Chromatin landscape and epigenetic heterogeneity of acute myeloid leukemiaSemantic proximity Read

Enhancer plasticity sustains oncogenic transformation and progression of B-Cell Acute Lymphoblastic leukemiaSemantic proximity Read

The genomic basis of childhood T-lineage acute lymphoblastic leukemiaSemantic proximity Read

The 3D genome of pediatric B-cell precursor acute lymphoblastic leukemiaSemantic proximity Read

SINGLE CELL DISSECTION OF DEVELOPMENTAL ORIGINS AND TRANSCRIPTIONAL HETEROGENEITY IN B-CELL ACUTE LYMPHOBLASTIC LEUKEMIASemantic proximity Read

Uncovering the regulatory landscape of early human B-cell lymphopoiesis and its implications in the pathogenesis of B-cell acute lymphoblastic leukemiaSemantic proximity Read

Enhancer retargeting of CDX2 and UBTF::ATXN7L3 define a subtype of high-risk B-progenitor acute lymphoblastic leukemiaSemantic proximity Read

Genome-wide association study of childhood B-cell acute lymphoblastic leukemia reveals novel African ancestry-specific susceptibility loci.Semantic proximity Read

The gene expression classifier ALLCatchR identifies B-precursor ALL subtypes and underlying developmental trajectories across ageSemantic proximity Read

The machine-learning classifier ALLCatchR2 identifies 20 T-ALL subtypes across cohorts and age groupsSemantic proximity Read