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Epigenomic mapping reveals distinct B cell acute lymphoblastic leukemia chromatin architectures and regulators

20 Nov 2023

Abstract excerpt

B cell lineage acute lymphoblastic leukemia (B-ALL) is composed of diverse molecular subtypes, and while transcriptional and DNA methylation profiling has been extensively examined, the chromatin landscape is not well characterized for many subtypes. We therefore mapped chromatin accessibility using ATAC-seq in primary B-ALL cells from 156 patients spanning ten molecular subtypes and present this dataset as a...

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PMID: 38116118
DOI: 10.1016/j.xgen.2023.100442

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