Article
Chromatin landscape and epigenetic heterogeneity of acute myeloid leukaemia.
Nature - 1 Aug 2026
Ochi Yotaro, Liew-Littorin Markus, Nannya Yasuhito, Bengtzen Sofia, Piauger Benedicte, Deneberg Stefan, Jädersten Martin, Lazarevic Vladimir, Cammenga Jörg, Robelius Anna, Wennström Lovisa, Ölander Emma, Kasahara Senji, Hiramoto Nobuhiro, Kanemura Nobuhiro, Sezaki Nobuo, Sakurada Maki, Iwasaki Makoto, Kanda Junya, Ueda Yasunori, Yoshihara Satoshi, Erkers Tom, Struyf Nona, Watanabe Yu, Motomura Masanori, Nakagawa Masahiro M, Saiki Ryunosuke, Fukushima Hidehito, Okazaki Koji, Morimoto Suguru, Yoda Akinori, Okuda Rurika, Komatsu Shintaro, Xie Guoxiang, Österroos Albin, Kon Ayana, Zhao Lanying, Shiraishi Yuichi, Ishikawa Takayuki, Miyano Satoru, Katayama Kotoe, Imoto Seiya, Matsuda Shuichi, Takaori-Kondo Akifumi, Aburatani Hiroyuki, Suzuki Hiroshi I, Kallioniemi Olli, Juliusson Gunnar, Höglund Martin, Lehmann Sören, Ogawa Seishi
Abstract excerpt
Acute myeloid leukaemia (AML) is an aggressive blood cancer characterized by the unregulated proliferation of immature myeloblasts. Gene mutations have been shown to have a large effect on pathogenesis, inter-tumour heterogeneity and clinical outcomes in AML1-8; however, the role of epigenetic alterations in these respects has been investigated less extensively. Here we use ATAC-seq (assay for...
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